abstract：BACKGROUND & AIMS:Robust data on hepatocellular carcinoma (HCC) incidence among HIV/hepatitis B virus (HBV)-coinfected individuals on antiretroviral therapy (ART) are needed to inform HCC screening strategies. We aimed to evaluate the incidence and risk factors of HCC among HIV/HBV-coinfected individuals on tenofovir d...

journal_title：Journal of hepatology

authors： Wandeler G,Mauron E,Atkinson A,Dufour JF,Kraus D,Reiss P,Peters L,Dabis F,Fehr J,Bernasconi E,van der Valk M,Smit C,Gjærde LK,Rockstroh J,Neau D,Bonnet F,Rauch A,Swiss HIV Cohort Study, Athena Observational Cohort Study

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition and the most common liver disease worldwide, affecting more than one-third of the population. So far there have been no reports on mendelian inheritance in families with NAFLD. METHODS:We performed whole-exome or targeted next-ge...

journal_title：Journal of hepatology

authors： Youssefian L,Vahidnezhad H,Saeidian AH,Pajouhanfar S,Sotoudeh S,Mansouri P,Amirkashani D,Zeinali S,Levine MA,Peris K,Colombo R,Uitto J

更新日期：2019-08-01 00:00:00

abstract：:Liver diseases affect millions of people worldwide. In most developed countries, the incidence of viral hepatitis is waning as a result of modern advances in disease prevention, diagnosis, and therapies. Expanded programmes for systematic immunisation against hepatitis B virus have also significantly brought down the ...

journal_title：Journal of hepatology

authors： Xiao J,Wang F,Wong NK,He J,Zhang R,Sun R,Xu Y,Liu Y,Li W,Koike K,He W,You H,Miao Y,Liu X,Meng M,Gao B,Wang H,Li C

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:Affordable point-of-care tests for hepatitis C (HCV) viraemia are needed to improve access to treatment in low- and middle-income countries. Our aims were to determine the target limit of detection (LOD) necessary to diagnose the majority of people with HCV eligible for treatment, and identify charact...

journal_title：Journal of hepatology

authors： Freiman JM,Wang J,Easterbrook PJ,Horsburgh CR,Marinucci F,White LF,Kamkamidze G,Krajden M,Loarec A,Njouom R,Nguyen KV,Shiha G,Soliman R,Solomon SS,Tsertsvadze T,Denkinger CM,Linas B

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIM:Chronic liver diseases are characterized by expansion of the small immature cholangiocytes - a mechanism named ductular reaction (DR) - which have the capacity to differentiate into hepatocytes. We investigated the kinetics of this differentiation, as well as analyzing several important features of the...

journal_title：Journal of hepatology

authors： Manco R,Clerbaux LA,Verhulst S,Bou Nader M,Sempoux C,Ambroise J,Bearzatto B,Gala JL,Horsmans Y,van Grunsven L,Desdouets C,Leclercq I

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND & AIMS:Diabetes occurring as a direct consequence of loss of liver function is usually characterized by non-diabetic fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) levels and should regress after orthotopic liver transplantation (OLT). This observational, longitudinal study investigated the relatio...

journal_title：Journal of hepatology

authors： Grancini V,Trombetta M,Lunati ME,Boselli ML,Gatti S,Donato MF,Palmieri E,Resi V,Pugliese G,Bonadonna RC,Orsi E

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND & AIMS:Accurate evaluation of renal function in patients with liver cirrhosis is critical for clinical management. However, there are still discrepancies between the measured glomerular filtration rate (mGFR) and creatinine-based estimated GFR (eGFR). In this study, we compared the performance of 2 common eG...

journal_title：Journal of hepatology

authors： Yoo JJ,Kim SG,Kim YS,Lee B,Lee MH,Jeong SW,Jang JY,Lee SH,Kim HS,Kim YD,Cheon GJ

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND & AIMS:Acute-on-chronic liver failure (ACLF) is characterised by the presence of organ failure in patients with decompensated cirrhosis and is associated with high short-term mortality. However, there are limited data on the prevalence and short-term outcomes of ACLF in patients with cirrhosis seen in the US...

journal_title：Journal of hepatology

authors： Hernaez R,Kramer JR,Liu Y,Tansel A,Natarajan Y,Hussain KB,Ginès P,Solà E,Moreau R,Gerbes A,El-Serag HB,Kanwal F

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:NGM282, an engineered analogue of the gut hormone FGF19, improves hepatic steatosis and fibrosis biomarkers in patients with non-alcoholic steatohepatitis (NASH). However, NGM282 increases serum cholesterol levels by inhibiting CYP7A1, which encodes the rate-limiting enzyme in the conversion of cholesterol t...

journal_title：Journal of hepatology

authors： Rinella ME,Trotter JF,Abdelmalek MF,Paredes AH,Connelly MA,Jaros MJ,Ling L,Rossi SJ,DePaoli AM,Harrison SA

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND & AIMS:Although there is increasing interest in its use, definitive evidence demonstrating a benefit for postmortem normothermic regional perfusion (NRP) in controlled donation after circulatory death (cDCD) liver transplantation is lacking. The aim of this study was to compare results of cDCD liver transpla...

journal_title：Journal of hepatology

authors： Hessheimer AJ,Coll E,Torres F,Ruíz P,Gastaca M,Rivas JI,Gómez M,Sánchez B,Santoyo J,Ramírez P,Parrilla P,Marín LM,Gómez-Bravo MÁ,García-Valdecasas JC,López-Monclús J,Boscá A,López-Andújar R,Fundora-Suárez J,Villar J,

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND & AIMS:In the sera of infected patients, hepatitis C virus (HCV) particles display heterogeneous forms with low-buoyant densities (<1.08), underscoring their lipidation via association with apoB-containing lipoproteins, which was proposed to occur during assembly or secretion from infected hepatocytes. Howev...

journal_title：Journal of hepatology

authors： Denolly S,Granier C,Fontaine N,Pozzetto B,Bourlet T,Guérin M,Cosset FL

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND & AIMS:Non-selective beta-blockers (NSBBs) are the mainstay of primary prophylaxis of esophageal variceal bleeding in patients with liver cirrhosis. We investigated whether non-invasive markers of portal hypertension correlate with hemodynamic responses to NSBBs in cirrhotic patients with esophageal varices....

journal_title：Journal of hepatology

authors： Kim HY,So YH,Kim W,Ahn DW,Jung YJ,Woo H,Kim D,Kim MY,Baik SK

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND & AIMS:Antibiotic resistance has been increasingly reported in patients with decompensated cirrhosis in single-center studies. Prospective investigations reporting broad epidemiological data are scarce. We aimed to analyze epidemiological changes in bacterial infections in patients with decompensated cirrhos...

journal_title：Journal of hepatology

authors： Fernández J,Prado V,Trebicka J,Amoros A,Gustot T,Wiest R,Deulofeu C,Garcia E,Acevedo J,Fuhrmann V,Durand F,Sánchez C,Papp M,Caraceni P,Vargas V,Bañares R,Piano S,Janicko M,Albillos A,Alessandria C,Soriano G,Welz

更新日期：2019-03-01 00:00:00

abstract：:Hepatitis viruses are major threats to human health. During the last decade, highly diverse viruses related to human hepatitis viruses were found in animals other than primates. Herein, we describe both surprising conservation and striking differences of the unique biological properties and infection patterns of human...

journal_title：Journal of hepatology

authors： Rasche A,Sander AL,Corman VM,Drexler JF

更新日期：2019-03-01 00:00:00

abstract：:Histological fibrosis stage is one of the most important prognostic factors in compensated and decompensated alcohol-related liver disease (ALD). Morphological assessment of fibrosis is useful for patient stratification, enabling individualised management, and for evaluation of treatment effects in clinical studies. I...

journal_title：Journal of hepatology

authors： Lackner C,Tiniakos D

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is a common cancer worldwide and remains a major clinical challenge. Ketoconazole, a traditional antifungal agent, has attracted considerable attention as a therapeutic option for cancer treatment. However, its mechanism of action is still not clearly defined. We aimed t...

journal_title：Journal of hepatology

authors： Chen Y,Chen HN,Wang K,Zhang L,Huang Z,Liu J,Zhang Z,Luo M,Lei Y,Peng Y,Zhou ZG,Wei Y,Huang C

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND & AIMS:The liver is the main hematopoietic site in embryos, becoming a crucial organ in both immunity and metabolism in adults. However, how the liver adapts both the immune system and enzymatic profile to challenges in the postnatal period remains elusive. We aimed to identify the mechanisms underlying this...

journal_title：Journal of hepatology

authors： Nakagaki BN,Mafra K,de Carvalho É,Lopes ME,Carvalho-Gontijo R,de Castro-Oliveira HM,Campolina-Silva GH,de Miranda CDM,Antunes MM,Silva ACC,Diniz AB,Alvarenga DM,Lopes MAF,de Souza Lacerda VA,Mattos MS,Araújo AM,Vidigal PV

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND & AIMS:Most cholesterol gallstones have a core consisting of inorganic and/or organic calcium salts, although the mechanisms of core formation are poorly understood. We examined whether the paracellular permeability of ions at hepatic tight junctions is involved in the core formation of cholesterol gallstone...

journal_title：Journal of hepatology

authors： Tanaka H,Imasato M,Yamazaki Y,Matsumoto K,Kunimoto K,Delpierre J,Meyer K,Zerial M,Kitamura N,Watanabe M,Tamura A,Tsukita S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND & AIMS:Recently, the PAGE-B score and Toronto HCC risk index (THRI) have been developed to predict the risk of hepatocellular carcinoma (HCC) in Caucasian patients with chronic hepatitis B (CHB). We aimed to validate PAGE-B scores and THRI in Asian patients with CHB and suggested modified PAGE-B scores to im...

journal_title：Journal of hepatology

authors： Kim JH,Kim YD,Lee M,Jun BG,Kim TS,Suk KT,Kang SH,Kim MY,Cheon GJ,Kim DJ,Baik SK,Choi DH

更新日期：2018-11-01 00:00:00

abstract：:Progressive familial intrahepatic cholestasis 2 is an autosomal-recessive disorder caused by mutations in the ABCB11 gene, which encodes the bile salt export pump (BSEP). Recurrence of BSEP deficiency after liver transplantation is caused by the development of anti-BSEP antibodies. Antibody-induced BSEP deficiency is ...

journal_title：Journal of hepatology

authors： Brinkert F,Pukite I,Krebs-Schmitt D,Briem-Richter A,Stindt J,Häussinger D,Keitel V,Müller I,Grabhorn E

更新日期：2018-10-01 00:00:00

abstract：:Worldwide, the increasingly dominant model of laboratory testing is the centralised laboratory, in which automation of analytical processes increases, enabling the analysis of large numbers of samples at a relatively low cost. However, this trend does not fulfil the requirements for care of patients with chronic hepat...

journal_title：Journal of hepatology

authors： Chevaliez S,Pawlotsky JM

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Fatty acid translocase CD36 (CD36) is a membrane protein with multiple immuno-metabolic functions. Palmitoylation has been suggested to regulate the distribution and functions of CD36, but little is known about its significance in non-alcoholic steatohepatitis (NASH). METHODS:Human liver tissue sam...

journal_title：Journal of hepatology

authors： Zhao L,Zhang C,Luo X,Wang P,Zhou W,Zhong S,Xie Y,Jiang Y,Yang P,Tang R,Pan Q,Hall AR,Luong TV,Fan J,Varghese Z,Moorhead JF,Pinzani M,Chen Y,Ruan XZ

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND & AIMS:γδ T cells comprise a substantial proportion of tissue-associated lymphocytes. However, our current understanding of human γδ T cells is primarily based on peripheral blood subsets, while the immunobiology of tissue-associated subsets remains largely unclear. Therefore, we aimed to elucidate the T cel...

journal_title：Journal of hepatology

authors： Hunter S,Willcox CR,Davey MS,Kasatskaya SA,Jeffery HC,Chudakov DM,Oo YH,Willcox BE

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND & AIMS:Absence or low anti-HBV surface antibody (anti-HBs) is associated with an increased risk of HBV reactivation in patients with lymphoma and resolved HBV infection receiving rituximab-containing chemotherapy. Quantification of anti-HBV core antibody (anti-HBc) is a new marker associated with the natural...

journal_title：Journal of hepatology

authors： Yang HC,Tsou HH,Pei SN,Chang CS,Chen JH,Yao M,Lin SJ,Lin J,Yuan Q,Xia N,Liu TW,Chen PJ,Cheng AL,Hsu C,Taiwan Cooperative Oncology Group.

更新日期：2018-08-01 00:00:00

abstract：:Hepatocytes synthesise the majority of serum proteins. This production occurs in the endoplasmic reticulum (ER) and is adjusted by complex local and systemic regulatory mechanisms. Accordingly, serum levels of hepatocyte-made proteins constitute important biomarkers that reflect both systemic processes and the status ...

journal_title：Journal of hepatology

authors： Kuscuoglu D,Janciauskiene S,Hamesch K,Haybaeck J,Trautwein C,Strnad P

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) and D virus (HDV) co-infections cause the most severe form of viral hepatitis. HDV induces an innate immune response, but it is unknown how the host cell senses HDV and if this defense affects HDV replication. We aim to characterize interferon (IFN) activation by HDV, identify ...

journal_title：Journal of hepatology

authors： Zhang Z,Filzmayer C,Ni Y,Sültmann H,Mutz P,Hiet MS,Vondran FWR,Bartenschlager R,Urban S

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND & AIMS:Several studies have shown that chronic hepatitis C (CHC) infection has a negative impact on kidney function, as well as survival, in patients with chronic kidney disease (CKD) or on hemodialysis. The aim of this nationwide registry study was to describe renal disease in Swedish patients with CHC. ME...

journal_title：Journal of hepatology

authors： Söderholm J,Millbourn C,Büsch K,Kövamees J,Schvarcz R,Lindahl K,Bruchfeld A

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary tract cancers (BTCs) are clinically and pathologically heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer understanding of their carcinogenesis, classification and treatment strategy. We performed large-scale genome sequencing analyses on BTCs to investigate t...

journal_title：Journal of hepatology

authors： Wardell CP,Fujita M,Yamada T,Simbolo M,Fassan M,Karlic R,Polak P,Kim J,Hatanaka Y,Maejima K,Lawlor RT,Nakanishi Y,Mitsuhashi T,Fujimoto A,Furuta M,Ruzzenente A,Conci S,Oosawa A,Sasaki-Oku A,Nakano K,Tanaka H,Yam

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND & AIMS:Heat shock protein (Hsp) 72 is a molecular chaperone that has broad cytoprotective functions and is upregulated in response to stress. To determine its hepatic functions, we studied its expression in human liver disorders and its biological significance in newly generated transgenic animals. METHODS:...

journal_title：Journal of hepatology

authors： Levada K,Guldiken N,Zhang X,Vella G,Mo FR,James LP,Haybaeck J,Kessler SM,Kiemer AK,Ott T,Hartmann D,Hüser N,Ziol M,Trautwein C,Strnad P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND & AIM:Virus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon (IFN-I) on myeloid cells, including liver-resident Kupffer cells (KC), is only partially understood. Herein, we dissected the impact of locally induced IFN-I responses...

journal_title：Journal of hepatology

authors： Borst K,Frenz T,Spanier J,Tegtmeyer PK,Chhatbar C,Skerra J,Ghita L,Namineni S,Lienenklaus S,Köster M,Heikenwaelder M,Sutter G,Kalinke U

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND & AIMS:Liver fibrosis regression but also progression may occur in patients with autoimmune hepatitis (AIH) under treatment. There is a need for non-invasive surrogate markers for fibrosis development in AIH to better guide immunosuppressive treatment. The aims of the study were to assess the impact of compl...

journal_title：Journal of hepatology

authors： Hartl J,Ehlken H,Sebode M,Peiseler M,Krech T,Zenouzi R,von Felden J,Weiler-Normann C,Schramm C,Lohse AW

更新日期：2018-04-01 00:00:00

abstract：:The clinical course of cirrhosis is mostly determined by the progressive increase of portal hypertension, hyperdynamic circulation, bacterial translocation and activation of systemic inflammation. Different disease states, encompassing compensated and decompensated cirrhosis and a late decompensated state, are related...

journal_title：Journal of hepatology

authors： D'Amico G,Morabito A,D'Amico M,Pasta L,Malizia G,Rebora P,Valsecchi MG

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND & AIMS:Primary non-function and ischaemic cholangiopathy are the most feared complications following donation-after-circulatory-death (DCD) liver transplantation. The aim of this study was to design a new score on risk assessment in liver-transplantation DCD based on donor-and-recipient parameters. METHODS:...

journal_title：Journal of hepatology

authors： Schlegel A,Kalisvaart M,Scalera I,Laing RW,Mergental H,Mirza DF,Perera T,Isaac J,Dutkowski P,Muiesan P

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic stellate cells (HSCs) have a role in liver fibrosis. Guanine nucleotide-binding α-subunit 12 (Gα12) converges signals from G-protein-coupled receptors whose ligand levels are elevated in the environment during liver fibrosis; however, information is lacking on the effect of Gα12 on HSC trans-d...

journal_title：Journal of hepatology

authors： Kim KM,Han CY,Kim JY,Cho SS,Kim YS,Koo JH,Lee JM,Lim SC,Kang KW,Kim JS,Hwang SJ,Ki SH,Kim SG

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND & AIMS:Statins are widely used to treat hypercholesterolemia. Statins may prevent hepatocellular carcinoma (HCC), but have not yet been fully studied, particularly in patients at high risk. Therefore, we investigated the risk of HCC after statin use in the whole general population and evaluated the effects o...

journal_title：Journal of hepatology

authors： Kim G,Jang SY,Nam CM,Kang ES

更新日期：2018-03-01 00:00:00

abstract：:Current medical practice artificially dichotomises a diagnosis of fatty liver disease into one of two common forms: alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Together, these account for the majority of chronic liver diseases worldwide. In recent years, there has been a dramatic incre...

journal_title：Journal of hepatology

authors： Boyle M,Masson S,Anstee QM

更新日期：2018-02-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD has traditionally been considered a consequence of metabolic syndrome (MetS). However, the link between NAFLD and MetS components, especially typ...

journal_title：Journal of hepatology

authors： Lonardo A,Nascimbeni F,Mantovani A,Targher G

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND & AIMS:Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxaliplatin in a novel ICC mouse model. METHODS...

journal_title：Journal of hepatology

authors： Zhang S,Song X,Cao D,Xu Z,Fan B,Che L,Hu J,Chen B,Dong M,Pilo MG,Cigliano A,Evert K,Ribback S,Dombrowski F,Pascale RM,Cossu A,Vidili G,Porcu A,Simile MM,Pes GM,Giannelli G,Gordan J,Wei L,Evert M,Cong W,C

更新日期：2017-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is among the most prevalent human malignancies worldwide with rising incidence in industrialised countries, few therapeutic options and poor prognosis. To expand and improve therapeutic strategies, identification of drug targets involved in several liver cancer-related pathways is crucia...

journal_title：Journal of hepatology

authors： Beck M,Schirmacher P,Singer S

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic hepatitis C virus (HCV)-infected patients with cirrhosis are a high-priority population for treatment. To help inform the benefit-risk profile of the all-oral direct-acting antiviral (DAA) combination regimen of ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir (OBV/PTV/r±DSV)...

journal_title：Journal of hepatology

authors： Poordad F,Nelson DR,Feld JJ,Fried MW,Wedemeyer H,Larsen L,Cohen DE,Cohen E,Mobashery N,Tatsch F,Foster GR

更新日期：2017-10-01 00:00:00